CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate
The signal mediated by sphingosine-1-phosphate receptor Action Figure Accessory Sets 1 (S1P1) is essential but seemingly insufficient for thymic export of newly generated T cells.Here, we reported the identification of CCR2 as an additional regulator of this process.CCR2 showed a markedly increased expression in the most mature subset of single-pos